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KMID : 0363320060270020416
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Journal of Korean Oriental Internal Medicine
2006 Volume.27 No. 2 p.416 ~ p.428
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Effects of Chungpyesagan-tang on arterial stiffness and pulse pressure in acute stroke patients
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Park Young-Min
Hong Jin-Woo
Shin Won-Jun
Jeong Dong-Won
Kim Suk-Min
Bae Hyung-Sup
Kim Young-Suk
Cho Ki-Ho
Moon Sang-Kwan
Jung Woo-Sang
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Abstract
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Objectives : Arterial stiffness and pulse pressure are related to cardiovascular and cerebrovascular survival and longevity. This study is aimed at examining the effects of Chungpyesagan-tang on arterial stiffness and Pulse pressure in acute stroke Patients.
Methods: The subject of this study was acute strike Patients within 1 week after ictus, with Cardio-ankle vascular index(CAVI) higher than 9.0. They were divided into two groups: A treatment group (n=44) and a control group(n=46). For two weeks, Chungpyesagan-tang was given to the former, other herbal medicines to the latter. used for stroke patients for the control group for 2 weeks. At the end of first and second week, CAVI, pulse Pressure, National Institute of Health stroke scale(NIHSS), Modified Barthel Index(MBI) were measured. Serum lipid Profile, aspartate transaminase(AST), alanine transaminase(ALT). blood urea nitrogen(BUN), creatinine were also measured at the end of the study.
Results : After 2 weeks, CAVI and Pulse Pressure in Chungpyesagan-tane group were significantly tower than those in the control group(P<0.05). NIHSS and MBI were improved in both groups. But there was no significant difference between the treatment group and the control group in terms of the NIHSS and MBI.
Conclusions : We suggest Chungpyesagan-tanghas desirable effects on arterial stiffness and Pulse Pressure of acute stroke patients. It can improve morbidity and mortality of patients on the basis of influencing vascular stiffness and increased pulse pressure.
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KEYWORD
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Chungpyesagan-tang, arterial stiffness, Carotid-Ankle Vascula, Index(CAVI), Pulse wave velocity(PWV), pulse pressure, stroke
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